Employing single-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our investigate passions consist of:
But how can morality, the dignity in the human being, my working experience on the which means of life, abide by with the movement of atoms? A purely naturalistic standpoint fails below; a Christian viewpoint, I do think, is a much more reasonable way to interpret these areas of reality.’
Multicolor imaging on the bacterial nucleoid and cell division proteins with blue, orange, and near-infrared fluorescent proteins
Considering that 2000, Dekker has shifted the principle emphasis of his operate in direction of biophysics the place he reports the Homes of solitary biomolecules and cells using the tools of nanotechnology. This change of field was pushed by his fascination with the amazing operating of biological molecular structures, as well as via the very long-expression viewpoint that many interesting discoveries is usually predicted On this area.[five] Recent traces of research in his biophysics team are during the regions of:[6]
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Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of just one wire bridging two electrodes
‘To start with we looked at biological programs which has a physical check out and acted on The idea of your resources we understood. It took a several years before we began Doing work extra on the big biological concerns. I then began to simply call it nanobiology, a time period that didn't exist at the time.
Nanopores stand for an elegant and versatile tool to measure one molecules. We research novel detection modes with solid-point out nanopores as well as various ways to evaluate proteins with nanopores. Jobs encompass the subsequent:
2003, shown the 1st biosensors manufactured from a carbon nanotube; settled the structure and mechanism of DNA repair proteins; and discovery of a completely new system for fabricating stable-condition nanopores for DNA translocation
1). The existing–voltage curves confirmed important modulations with gate voltage, even at area temperature, which was in step with band bending within https://www.ceesdekker.net a ~0.6 eV bandgap semiconducting nanotube. These details also confirmed the conductance might be modulated by 6 orders of magnitude by transforming the gate voltage. The final results of this work — a home-temperature transistor constructed from one carbon nanotube molecule — have been printed in Mother nature in May well 1998.
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Example (two) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim on the pore is highlighted in red, plus a 3D rendering from the movement of the DNA rod is shown.